Yixuan (Jacob) Hou

Food Animal Health Research Program
1680 Madison Ave., Wooster, OH 44691
Phone: 330-202-3567
Fax: 330-263-3677
Email: hou.214@osu.edu

Biographical Information

  • Ph.D. student/Graduate research associate, Comparative Veterinary Medicine, The Ohio State University U.S. (September 2014 – Present)
  • M.S., Veterinary Preventive Medicine, Shanghai Jiao Tong University, Shanghai, China, (2011 – 2014)
  • B.S., Biology, Shanghai Ocean University, Shanghai, China (2007 – 2011)

Research Area

  • Developing a reverse genetic system for porcine epidemic diarrhea virus (PEDV).
  • Investigating pathogenesis and cellular receptor binding for PEDV-PC177, a strain with large deletion on N-terminus of S1 domain.
  • Prokaryotic expression of non-structural proteins of an U.S. PEDV strain PC22A.
  • Pathogenesis studies of different PEDV strains.

Selected Publications


  1. Hou Y, Lin CM, Yokoyama M, Yount BL, Marthaler D, Douglas AL, Ghimire S, Qin Y, Baric RS, Saif LJ*, and Wang Q*. Deletion of a 197 amino acid-region in the N-terminal domain of spike protein attenuates porcine epidemic diarrhea virus. J Virol. 91 (14).
  2. Lin CM, Hou Y, Marthaler D, Gao X, Liu X, Zhang L, Saif LJ, Wang Q. Attenuation of an Original US Porcine Epidemic Virus Strain PC22A via Serial Cell Culture Passage. Veterinary Microbiology. 2017; 201(62-71):
  3. Beall A, Yount B, Lin CM, Hou Y, Wang Q, Saif L, Baric R. Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A. mBio. 2016; 7(1):e01451-15.
  4. Hou Y, Yue X, Cai X, Wang S, Liu Y, Yuan C, Cui L, Hua X, and Yang Z. 2012 Complete Genome of Transmissible Gastroenteritis Virus AYU Strain Isolated in Shanghai, China J. Virol. 2012, 86(21):11935

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