Dr. Scott Kenney

Assistant Professor

Food Animal Health Research Program
168 Food Animal Health/207 Hayden
OARDC Wooster, OH 44691
Phone: (330) 263-3747
Fax:(330) 263-3677
Email: kenney.157@osu.edu

Biographical Information

  • BS, 2002, Pennsylvania State University College of Medicine, Microbiology & Immunology
  • PhD, 2008, Pennsylvania State University, Animal Bioscience

Research Area

Hepatitis E Virus (HEV) is an emerging zoonotic disease afflicting developing countries in Africa, Asia and the Americas where large outbreaks occur due to lack of sanitary drinking water. In developed countries in Europe and the Americas HEV is a zoonotic pathogen shown to pass primarily from pigs and pork products to humans. While generally healthy adults can fight off HEV, in pregnant women there is up to a 30% mortality rate and HEV can cause chronic hepatitis in immunocompromised individuals. There are currently 7 known genotypes within the Orthohepevirus A species (of human health concern). Genotype-1 infects humans and is found in Asia and Africa, genotype 2 also specifically infects humans and is more common in Mexico. Genotypes 3 and 4 are known to infect humans as well as swine, deer, rabbits, and mongoose. Genotypes 5, 6, and 7 infect animals including wild boar and camel. Orthohepevirus B-D infect chickens, bats, and ferrets, respectively, but are not known to infect humans.

Historically HEV has been difficult to propagate in cell culture and animal models were limited to pigs and chickens, limiting much of our understanding of the molecular aspects of HEV infection. Part of our ongoing research focuses on understanding cross species transmission of the virus, the factors required for efficient virus growth, and the creation of better small animal models to study this virus. Using this knowledge we hope to discover more about how HEV interacts with its hosts and create therapies to treat it.

Selected Publications

2016

  1. Carnaccini S, Shivaprasad HL, Cutler G, Bland M, Meng XJ, Kenney SP, Bickford
    AA, Cooper G, Charlton B, Sentíes-Cué CG. Characterization of Seven Outbreaks of
    Hemorrhagic Hepatopathy Syndrome in Commercial Pullets Following the
    Administration of a Salmonella Enteritidis Bacterin in California. Avian Dis.
    2016 Mar;60(1):33-42. doi: 10.1637/11297-100915-Reg.1. PubMed PMID: 26953941.
  2. Piñeyro PE, Kenney SP, Giménez-Lirola LG, Opriessnig T, Tian D, Heffron CL,
    Meng XJ. Evaluation of the use of non-pathogenic porcine circovirus type 1 as a
    vaccine delivery virus vector to express antigenic epitopes of porcine
    reproductive and respiratory syndrome virus. Virus Res. 2016 Feb 2;213:100-8.
    doi: 10.1016/j.virusres.2015.11.005. Epub 2015 Nov 7. PubMed PMID: 26555162.

2015

  1. Kenney SP, Wentworth JL, Heffron CL, Meng XJ. Replacement of the hepatitis E
    virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus
    release via interaction with TSG101. Virology. 2015 Dec;486:198-208. doi:
    10.1016/j.virol.2015.09.012. Epub 2015 Oct 27. PubMed PMID: 26457367; PubMed
    Central PMCID: PMC4679584.
  2. Piñeyro PE, Kenney SP, Giménez-Lirola LG, Heffron CL, Matzinger SR, Opriessnig
    T, Meng XJ. Expression of antigenic epitopes of porcine reproductive and
    respiratory syndrome virus (PRRSV) in a modified live-attenuated porcine
    circovirus type 2 (PCV2) vaccine virus (PCV1-2a) as a potential bivalent vaccine
    against both PCV2 and PRRSV. Virus Res. 2015 Dec 2;210:154-64. doi:
    10.1016/j.virusres.2015.07.027. Epub 2015 Jul 31. PubMed PMID: 26239318.
  3. Kenney SP, Meng XJ. Therapeutic targets for the treatment of hepatitis E virus
    infection. Expert Opin Ther Targets. 2015;19(9):1245-60. doi:
    10.1517/14728222.2015.1056155. Epub 2015 Jun 13. Review. PubMed PMID: 26073772;
    PubMed Central PMCID: PMC4834873.
  4. Kenney SP, Meng XJ. An SH3 binding motif within the nucleocapsid protein of
    porcine reproductive and respiratory syndrome virus interacts with the host
    cellular signaling proteins STAMI, TXK, Fyn, Hck, and cortactin. Virus Res. 2015
    Jun 2;204:31-9. doi: 10.1016/j.virusres.2015.04.004. Epub 2015 Apr 13. PubMed
    PMID: 25882913.
  5. Kenney SP, Meng XJ. Identification and fine mapping of nuclear and nucleolar
    localization signals within the human ribosomal protein S17. PLoS One. 2015 Apr
    8;10(4):e0124396. doi: 10.1371/journal.pone.0124396. eCollection 2015. PubMed
    PMID: 25853866; PubMed Central PMCID: PMC4390217.
  6. Kenney SP, Meng XJ. The lysine residues within the human ribosomal protein S17
    sequence naturally inserted into the viral nonstructural protein of a unique
    strain of hepatitis E virus are important for enhanced virus replication. J
    Virol. 2015 Apr;89(7):3793-803. doi: 10.1128/JVI.03582-14. Epub 2015 Jan 21.
    PubMed PMID: 25609799; PubMed Central PMCID: PMC4403402.