Dr. Scott Kenney
Food Animal Health Research Program
168 Food Animal Health/207 Hayden
OARDC Wooster, OH 44691
Phone: (330) 263-3747
Animal Health, Veterinary Epidemiology, Infectious Disease Epidemiology, Veterinary Diagnostics, Veterinary Preventive Medicine, Veterinary Microbiology, Veterinary Infectious Diseases, Veterinary Virology, Veterinary Vaccine Production
Hepatitis E Virus (HEV) is an emerging zoonotic disease afflicting developing countries in Africa, Asia and the Americas where large outbreaks occur due to lack of sanitary drinking water. In developed countries in Europe and the Americas HEV is a zoonotic pathogen shown to pass primarily from pigs and pork products to humans. While generally healthy adults can fight off HEV, in pregnant women there is up to a 30% mortality rate and HEV can cause chronic hepatitis in immunocompromised individuals. There are currently 7 known genotypes within the Orthohepevirus A species (of human health concern). Genotype-1 infects humans and is found in Asia and Africa, genotype 2 also specifically infects humans and is more common in Mexico. Genotypes 3 and 4 are known to infect humans as well as swine, deer, rabbits, and mongoose. Genotypes 5, 6, and 7 infect animals including wild boar and camel. Orthohepevirus B-D infect chickens, bats, and ferrets, respectively, but are not known to infect humans.
Historically HEV has been difficult to propagate in cell culture and animal models were limited to pigs and chickens, limiting much of our understanding of the molecular aspects of HEV infection. Part of our ongoing research focuses on understanding cross species transmission of the virus, the factors required for efficient virus growth, and the creation of better small animal models to study this virus. Using this knowledge we hope to discover more about how HEV interacts with its hosts and create therapies to treat it.
Kenney SP, Meng XJ. Therapeutic targets for the treatment of hepatitis E virus infection. Expert Opin Ther Targets. 2015;19(9):1245-60. doi:10.1517/14728222.2015.1056155. Epub 2015 Jun 13. Review. PubMed PMID: 26073772; PubMed Central PMCID: PMC4834873.
Kenney SP, Meng XJ. The lysine residues within the human ribosomal protein S17
sequence naturally inserted into the viral nonstructural protein of a unique
strain of hepatitis E virus are important for enhanced virus replication. JVirol. 2015 Apr;89(7):3793-803. doi: 10.1128/JVI.03582-14. Epub 2015 Jan 21.PubMed PMID: 25609799; PubMed Central PMCID: PMC4403402.
Kenney SP, Meng XJ. Identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein S17. PLoS One. 2015 Apr 8;10(4):e0124396. doi: 10.1371/journal.pone.0124396. eCollection 2015. PubMed PMID: 25853866; PubMed Central PMCID:PMC4390217.
Kenney SP, Meng XJ. An SH3 binding motif within the nucleocapsid protein of porcine reproductive and respiratory syndrome virus interacts with the host cellular signaling proteins STAMI, TXK, Fyn, Hck, and cortactin. Virus Res. 2015 Jun 2;204:31-9. doi:10.1016/j.virusres.2015.04.004. Epub 2015 Apr 13. PubMed PMID: 25882913.
Kenney SP, Wentworth JL, Heffron CL, Meng XJ. Replacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus release via interaction with TSG101. Virology. 2015 Dec;486:198-208. doi:10.1016/j.virol.2015.09.012. Epub 2015 Oct 27. PubMed PMID: 26457367; PubMed Central PMCID: PMC4679584.
Piñeyro PE, Kenney SP, Giménez-Lirola LG, Opriessnig T, Tian D, Heffron CL, Meng XJ. Evaluation of the use of non-pathogenic porcine circovirus type 1 as avaccine delivery virus vector to express antigenic epitopes of porcine reproductive and respiratory syndrome virus. Virus Res. 2016 Feb 2;213:100-8. doi: 10.1016/j.virusres.2015.11.005. Epub 2015 Nov 7. PubMed PMID:26555162.
Piñeyro PE, Kenney SP, Giménez-Lirola LG, Heffron CL, Matzinger SR, Opriessnig T, Meng XJ. Expression of antigenic epitopes of porcine reproductive and respiratory syndrome virus (PRRSV) in a modified live-attenuated porcine circovirus type 2 (PCV2) vaccine virus (PCV1-2a) as a potential bivalent vaccine against both PCV2 and PRRSV. Virus Res. 2015 Dec 2;210:154-64. doi: 10.1016/j.virusres.2015.07.027. Epub 2015 Jul 31. PubMed PMID: 26239318.
Carnaccini S, Shivaprasad HL, Cutler G, Bland M, Meng XJ, Kenney SP, Bickford AA, Cooper G, Charlton B, Sentíes-Cué CG. Characterization of Seven Outbreaks of Hemorrhagic Hepatopathy Syndrome in Commercial Pullets Following the Administration of a Salmonella Enteritidis Bacterin in California. Avian Dis. 2016 Mar;60(1):33-42. doi: 10.1637/11297-100915-Reg.1. PubMed PMID: 26953941.