Wang Laboratory

Dr. Qiuhong Wang
Food Animal Health Research Program

Food Animal Health – OARDC
Wooster, OH 44691
Phone: 330-263-3960
Fax: 330-263-3760
Email: wang.655@osu.edu

Areas of Expertise

  • Virology
  • Emerging and re-emerging infectious diseases
  • Molecular mechanisms of attenuation and vaccine development
  • Food safety
  • Cell culture adaptation of enteric viruses
  • Interspecies transmission
  • Model viruses of study: porcine epidemic diarrhea virus (PEDV), caliciviruses (norovirus, sapovirus, etc.)

Research Interests

My current research focus is on enteric caliciviruses and coronaviruses, including diagnosis of viral infections, molecular epidemiology, molecular characterization of new viruses, propagation of enteric viruses in cell culture, molecular mechanisms of cell culture adaptation and attenuation, interspecies transmission of viruses between humans and animals, the mechanism of enteric virus transmission through leafy greens, and the development of vaccines.

Laboratory Personnel

Selected Publications

  1. Oka T, Stoltzfus GT, Zhu C, Jung K, Wang Q*, and Saif LJ*.  Attempts to grow human noroviruses, a sapovirus and animal noroviruses in vitro. Plos One. (Accepted on May 17, 2017)
  2. Hou Y, Lin CM, Yokoyama M, Yount BL, Marthaler D, Douglas AL, Ghimire S, Qin Y, Baric RS, Saif LJ*, and Wang Q*. Deletion of a 197 amino acid-region in the N-terminal domain of spike protein attenuates porcine epidemic diarrhea virus. J Virol. 91 (14).
  3. Lin CM, Hou Y, Marthaler D, Gao X, Liu X, Zhang L, Saif LJ, Wang Q. Attenuation of an Original US Porcine Epidemic Virus Strain PC22A via Serial Cell Culture Passage. Veterinary Microbiology. 2017; 201(62-71):
  4. Oka T, Lu Z, Phan T, Delwart EL, Saif LJ, Wang Q. Genetic Characterization and Classification of Human and Animal Sapoviruses. PloS one. 2016; 11(5):e0156373.
  5. Liu X, Wang Q. Reverse transcription-PCR assays for the differentiation of various US porcine epidemic diarrhea virus strains. J Virol Methods. 2016 Aug;234:137-41. doi: 10.1016/j.jviromet.2016.04.018. Epub 2016 Apr 28.
  6. Beall A, Yount B, Lin CM, Hou Y, Wang Q, Saif L, Baric R. Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A. mBio. 2016; 7(1):e01451-15.
  7. Gao X, Esseili MA, Lu Z, Saif LJ, Wang Q. Recognition of Histo-Blood Group Antigen-Like Carbohydrates in Lettuce by Human GII.4 Norovirus. Applied and environmental microbiology. 2016; 82(10):2966-74.
  8. Lin CM, Saif LJ, Marthaler D, Wang Q. Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains. Virus research. 2016. Jun 8. pii: S0168-1702(16)30225-8.
  9. Esseili MA, Chin A, Saif LJ, Miller SA, Qu F, Lewis Ivey ML, Wang Q. Postharvest survival of porcine sapovirus, a human norovirus surrogate, on phytopathogen infected leafy greens. Journal of food protection. 2015; 78:1472-80.
  10. Oka T, Wang Q, Katayama K, Saif LJ. Comprehensive review of human sapoviruses. Clinical microbiology reviews. 2015; 28(1):32-53.
  11. Lin CM, Gao X, Oka T, Vlasova AN, Esseili MA, Wang Q, Saif LJ. Antigenic relationships among porcine epidemic diarrhea virus and transmissible gastroenteritis virus strains. Journal of virology. 2015; 89(6):3332-42.
  12. Hu H, Jung K, Vlasova AN, Chepngeno J, Lu Z, Wang Q, Saif LJ. Isolation and characterization of porcine deltacoronavirus from pigs with diarrhea in the United States. Journal of clinical microbiology. 2015; 53(5):1537-48.
  13. Esseili MA, Saif LJ, Farkas T, Wang Q. Feline Calicivirus, Murine Norovirus, Porcine Sapovirus, and Tulane Virus Survival on Postharvest Lettuce. Applied and environmental microbiology. 2015; 81(15):5085-92.
  14. Liu X*, Lin CM*, Annamalai T, Gao X, Lu Z, Esseili MA, Jung K, El-Tholoth M, Saif LJ, Wang Q. Determination of the infectious titer and virulence of an original US porcine epidemic diarrhea virus PC22A strain. Veterinary research. 2015; 46:109.
  15. Esseili MA, Gao X, Tegtmeier S, Saif LJ, Wang Q. Abiotic Stress and Phyllosphere Bacteria Influence the Survival of Human Norovirus and Its Surrogates on Preharvest Leafy Greens. Applied and environmental microbiology. 2015; 82(1):352-63.
  16. Lin CM, Annamalai T, Liu X, Gao X, Lu Z, El-Tholoth M, Hu H, Saif LJ, Wang Q. Experimental infection of a US spike-insertion deletion porcine epidemic diarrhea virus in conventional nursing piglets and cross-protection to the original US PEDV infection. Veterinary research. 2015; 46:134.
PubMed